Dynamic Telomerase Gene Suppression via Network Effects of GSK3 Inhibition

BACKGROUND: Telomerase controls telomere homeostasis and cell immortality and is a promising anti-cancer target, but few small molecule telomerase inhibitors have been developed. Reactivated transcription of the catalytic subunit hTERT in cancer cells controls telomerase expression. Better understan...

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Autors principals: Bilsland, Alan E., Hoare, Stacey, Stevenson, Katrina, Plumb, Jane, Gomez-Roman, Natividad, Cairney, Claire, Burns, Sharon, Lafferty-Whyte, Kyle, Roffey, Jon, Hammonds, Tim, Keith, W. Nicol
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714081/
https://ncbi.nlm.nih.gov/pubmed/19649288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006459
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