Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer

BACKGROUND: Cytoglobin (Cygb) was first described in 2002 as an intracellular globin of unknown function. We have previously shown the downregulation of cytoglobin as a key event in a familial cancer syndrome of the upper aerodigestive tract. METHODS: Cytoglobin expression and promoter methylation w...

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Главные авторы: Shaw, R J, Omar, M M, Rokadiya, S, Kogera, F A, Lowe, D, Hall, G L, Woolgar, J A, Homer, J, Liloglou, T, Field, J K, Risk, J M
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2009
Предметы:
Molecular Diagnostics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713706/
https://ncbi.nlm.nih.gov/pubmed/19568272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605121
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