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A novel hirudin derivative characterized with anti-platelet aggregations and thrombin inhibition
Background Hirudin is an anti-coagulative product of the salivary glands of the medicinal leech Hirudo medicinalis. It is a powerful and specific thrombin inhibitor. Peptides containing the RGD motif competitively inhibit the binding of fibrinogen to GP IIb/IIIa on the platelets, thus inhibiting pla...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer US
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713024/ https://ncbi.nlm.nih.gov/pubmed/18998199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11239-008-0251-9 |
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