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NMR Dynamics of PSE-4 β-Lactamase: An Interplay of ps-ns Order and μs-ms Motions in the Active Site

The backbone dynamics for the 29.5 kDa class A β-lactamase PSE-4 is presented. This solution NMR study was performed using multiple field (15)N spin relaxation and amide exchange data in the EX2 regime. Analysis was carried out with the relax program and includes the Lipari-Szabo model-free approach...

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Bibliographic Details
Main Authors: Morin, Sébastien, Gagné, Stéphane M.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711454/
https://ncbi.nlm.nih.gov/pubmed/19486690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.02.068
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