Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-κB and AP-1

BACKGROUND AND PURPOSE: Endothelin-1 (ET-1) is implicated in airway inflammation in asthma, but the mechanisms of its effects are poorly understood. We studied the effect of ET-1 on expression of the chemokine, monocyte chemotactic protein-1 (MCP-1), in primary cultures of human airway smooth muscle...

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Detalhes bibliográficos
Main Authors: Sutcliffe, Amy M, Clarke, Deborah L, Bradbury, Dawn A, Corbett, Lisa M, Patel, Jamie A, Knox, Alan J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707990/
https://ncbi.nlm.nih.gov/pubmed/19371341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00143.x
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