Specific activation of 2'-5'oligoadenylate synthetase gene promoter by hepatitis C virus-core protein: A potential for developing hepatitis C virus targeting gene therapy

AIM: To examine whether 2'-5'oligoadenylate synthetase (OAS) gene promoter can be specifically activated by hepatitis C virus (HCV)-core protein. METHODS: Human embryo hepatic cell line L02 was transfected with pcDNA3.1-core plasmid and selected by G418. Expression of HCV-core was detected...

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Hlavní autoři: Wang, Ying, Mao, Shan-Shan, He, Qiong-Qiong, Zi, Yuan, Wen, Ji-Fang, Feng, De-Yun
Médium: Artigo
Jazyk:Inglês
Vydáno: The WJG Press and Baishideng 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705743/
https://ncbi.nlm.nih.gov/pubmed/19575500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.15.3178
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