Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

Poly(ADP-ribose) polymerase 1 (PARP1) synthesizes poly(ADP-ribose) (PAR) using nicotinamide adenine dinucleotide (NAD) as a substrate. Despite intensive research on the cellular functions of PARP1, the molecular mechanism of PAR formation has not been comprehensively understood. In this study, we el...

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Autores principales: Altmeyer, Matthias, Messner, Simon, Hassa, Paul O., Fey, Monika, Hottiger, Michael O.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
Nucleic Acids Enzymes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699514/
https://ncbi.nlm.nih.gov/pubmed/19372272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp229
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