Genetic Variation in Complement Component 2 of the Classical Complement Pathway is Associated with Increased Mortality and Infection: A Study of 627 Trauma Patients

Trauma is a disease of inflammation. Complement Component 2 (C2) is a protease involved in activation of complement through the classical pathway and has been implicated in a variety of chronic inflammatory diseases. We hypothesized that genetic variation in C2 (E318D) identifies a high-risk subgrou...

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Hlavní autoři: Morris, John A., Francois, Cedric, Olson, Paul K., Cotton, Bryan A., Summar, Marshall, Jenkins, Judith M., Norris, Patrick R., Moore, Jason H., Williams, Anna E., McNew, Brent S., Canter, Jeffrey A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697907/
https://ncbi.nlm.nih.gov/pubmed/19430225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0b013e31819ea61a
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