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Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy
BACKGROUND: Aberrant activation NF-kappaB has been proposed as a mechanism of drug resistance in pancreatic cancer. Recently, inhibition of glycogen synthase kinase-3 has been shown to exert anti-tumor effects on pancreatic cancer cells by suppressing NF-kappaB. Consequently, we investigated whether...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2009
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685435/ https://ncbi.nlm.nih.gov/pubmed/19405981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-132 |
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