Insufficiency of Pro-heparin-binding Epidermal Growth Factor-like Growth Factor Shedding Enhances Hypoxic Cell Death in H9c2 Cardiomyoblasts via the Activation of Caspase-3 and c-Jun N-terminal Kinase

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a cardiogenic and cardiohypertrophic growth factor. ProHB-EGF, a product of the Hb-egf gene and the precursor of HB-EGF, is anchored to the plasma membrane. Its ectodomain region is shed by a disintegrin and metalloproteases (ADA...

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Bibliographic Details
Main Authors: Uetani, Teruyoshi, Nakayama, Hironao, Okayama, Hideki, Okura, Takafumi, Higaki, Jitsuo, Inoue, Hirofumi, Higashiyama, Shigeki
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Molecular Basis of Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673307/
https://ncbi.nlm.nih.gov/pubmed/19193634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900463200
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