Probing the Functional Impact of Sequence Variation on p53-DNA Interactions Using a Novel Microsphere Assay for Protein-DNA Binding with Human Cell Extracts

The p53 tumor suppressor regulates its target genes through sequence-specific binding to DNA response elements (REs). Although numerous p53 REs are established, the thousands more identified by bioinformatics are not easily subjected to comparative functional evaluation. To examine the relationship...

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Main Authors: Noureddine, Maher A., Menendez, Daniel, Campbell, Michelle R., Bandele, Omari J., Horvath, Monica M., Wang, Xuting, Pittman, Gary S., Chorley, Brian N., Resnick, Michael A., Bell, Douglas A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2009
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667269/
https://ncbi.nlm.nih.gov/pubmed/19424414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000462
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