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Multivalency-Assisted Control of Intracellular Signaling Pathways: Application for Ubiquitin-Dependent N-End Rule Pathway

Intracellular signaling is often mediated by a family of functionally overlapping signal mediators that contain multiple sites interacting with other proteins or ligands with weak affinity (K(d) > μM). Conjugation of multiple low-affinity ligands into a high-affinity multivalent molecule provides...

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Detalhes bibliográficos
Main Authors: Sriram, Shashikanth M., Banerjee, Rajkumar, Kane, Ravi S., Kwon, Yong Tae
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665046/
https://ncbi.nlm.nih.gov/pubmed/19246002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.01.012
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