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Accelerated Metabolism of Voriconazole and Its Partial Reversal by Cimetidine

We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of cimetidine as a cytoc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Moriyama, Brad, Elinoff, Jason, Danner, Robert L., Gea-Banacloche, Juan, Pennick, Gennethel, Rinaldi, Michael G., Walsh, Thomas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663057/
https://ncbi.nlm.nih.gov/pubmed/19171800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01221-08
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