KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract

In Kruppel-like factor (KLF)-4-deficient mice, colonic goblet cell numbers are significantly reduced. Goblet cell development is regulated by the Notch signaling pathway. The aim of this study was to examine whether Notch represses KLF4 expression to regulate goblet cell differentiation. We first de...

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Bibliographic Details
Main Authors: Zheng, Hai, Pritchard, D. Mark, Yang, Xiangdong, Bennett, Elaine, Liu, Gang, Liu, Chunming, Ai, Walden
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
Subjects:
Mucosal Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660173/
https://ncbi.nlm.nih.gov/pubmed/19109406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90393.2008
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