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Enhanced Cancer Cell Growth Inhibition by Dipeptide Prodrugs of Floxuridine: Increased Transporter Affinity and Metabolic Stability
[Image: see text] Dipeptide monoester prodrugs of floxuridine were synthesized, and their chemical stability in buffers, resistance to glycosidic bond metabolism, affinity for PEPT1, enzymatic activation and permeability in cancer cells were determined and compared to those of mono amino acid monoes...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659690/ https://ncbi.nlm.nih.gov/pubmed/18652477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp800008c |
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