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Inhibition of ERK Promotes Collagen Gel Compaction and Fibrillogenesis to Amplify the Osteogenesis of Human Mesenchymal Stem Cells in Three-Dimensional Collagen I Culture

Tissue morphogenesis remains one of the least understood problems in cell and developmental biology. There is a disconnect between the mechanisms that apply to two-dimensional (2D) cultures and those seen in vivo. Three-dimensional (3D) culture presents a complex stimulus triggering cellular respons...

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Bibliographic Details
Main Authors: Lund, Amanda W., Stegemann, Jan P., Plopper, George E.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656582/
https://ncbi.nlm.nih.gov/pubmed/18491946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2008.0075
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