Factors Influencing the Statistical Power of Complex Data Analysis Protocols for Molecular Signature Development from Microarray Data

BACKGROUND: Critical to the development of molecular signatures from microarray and other high-throughput data is testing the statistical significance of the produced signature in order to ensure its statistical reproducibility. While current best practices emphasize sufficiently powered univariate...

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Main Authors: Aliferis, Constantin F., Statnikov, Alexander, Tsamardinos, Ioannis, Schildcrout, Jonathan S., Shepherd, Bryan E., Harrell, Frank E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654113/
https://ncbi.nlm.nih.gov/pubmed/19290050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004922
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