Initiation of V(D)J Recombination by Dβ-Associated Recombination Signal Sequences: A Critical Control Point in TCRβ Gene Assembly

T cell receptor (TCR) β gene assembly by V(D)J recombination proceeds via successive Dβ-to-Jβ and Vβ-to-DJβ rearrangements. This two-step process is enforced by a constraint, termed beyond (B)12/23, which prohibits direct Vβ-to-Jβ rearrangements. However the B12/23 restriction does not explain the o...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Franchini, Don-Marc, Benoukraf, Touati, Jaeger, Sébastien, Ferrier, Pierre, Payet-Bornet, Dominique
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2009
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642999/
https://ncbi.nlm.nih.gov/pubmed/19238214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004575
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