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Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria

gC1qR is one of the C1q receptors implicated in the regulation of innate and adaptive immunity. We found that gC1qR inhibits RIG-I and MDA5-dependent antiviral signaling. Double stranded RNA and virus trigger the translocation of gC1qR to the mitochondrial outer membrane leading to the interaction o...

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Autori principali: Xu, Lijuan, Xiao, Nengming, Liu, Feng, Ren, Hongwei, Gu, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635802/
https://ncbi.nlm.nih.gov/pubmed/19164550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811029106
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