Sustained Platelet-Derived Growth Factor Receptor α Signaling in Osteoblasts Results in Craniosynostosis by Overactivating the Phospholipase C-γ Pathway

The development and growth of the skull is controlled by cranial sutures, which serve as growth centers for osteogenesis by providing a pool of osteoprogenitors. These osteoprogenitors undergo intramembranous ossification by direct differentiation into osteoblasts, which synthesize the components of...

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Bibliographic Details
Main Authors: Moenning, Anne, Jäger, Richard, Egert, Angela, Kress, Wolfram, Wardelmann, Eva, Schorle, Hubert
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630675/
https://ncbi.nlm.nih.gov/pubmed/19047372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00885-08
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