Pharmacokinetics and Bioequivalence Evaluation of Two Fixed-Dose Tablet Formulations of Dihydroartemisinin and Piperaquine in Vietnamese Subjects

The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were onl...

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Bibliographic Details
Main Authors: Chinh, Nguyen Trong, Quang, Nguyen Ngoc, Thanh, Nguyen Xuan, Dai, Bui, Geue, Jason P., Addison, Russell S., Travers, Thomas, Edstein, Michael D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630617/
https://ncbi.nlm.nih.gov/pubmed/19047656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00927-08
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