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Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo
Adenoviral gene transfer of sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA)2a to the hypertrophic heart in vivo has been consistently reported to lead to enhanced myocardial contractility. It is unknown if the faster skeletal muscle isoform, SERCA1, expressed in the whole heart in early failure,...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2614552/ https://ncbi.nlm.nih.gov/pubmed/18952713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01023.2008 |
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