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Extracellular Protons Regulate Human ENaC by Modulating Na(+) Self-inhibition
The epithelial Na(+) channel, ENaC, is exposed to a wide range of proton concentrations in the kidney, lung, and sweat duct. We, therefore, tested whether pH alters ENaC activity. In Xenopus oocytes expressing human α-, β-, and γENaC, amiloride-sensitive current was altered by protons in the physiol...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2613628/ https://ncbi.nlm.nih.gov/pubmed/18990692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806954200 |
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