Effect of Concomitant Artesunate Administration and Cytochrome P4502C8 Polymorphisms on the Pharmacokinetics of Amodiaquine in Ghanaian Children with Uncomplicated Malaria

Artesunate (AS) is used in combination with amodiaquine (AQ) as first-line treatment for uncomplicated malaria in many countries. We investigated the effect of concomitant AS administration on the pharmacokinetics of AQ and compared concentrations of desethylamodiaquine (DEAQ), the main metabolite o...

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Hauptverfasser: Adjei, George O., Kristensen, Kim, Goka, Bamenla Q., Hoegberg, Lotte C. G., Alifrangis, Michael, Rodrigues, Onike P., Kurtzhals, Jorgen A. L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Clinical Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592852/
https://ncbi.nlm.nih.gov/pubmed/18779360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00673-07
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