Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea

Sox2 is a high-mobility transcription factor that is one of the earliest markers of developing inner ear prosensory domains. In humans, mutations in SOX2 cause sensorineural hearing loss and a loss of function study in mice showed that Sox2 is required for prosensory formation in the cochlea. Howeve...

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Bibliographic Details
Main Authors: Dabdoub, Alain, Puligilla, Chandrakala, Jones, Jennifer M., Fritzsch, Bernd, Cheah, Kathryn S. E., Pevny, Larysa H., Kelley, Matthew W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587543/
https://ncbi.nlm.nih.gov/pubmed/19011097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808175105
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