Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice

Polymorphisms of IL-1β are associated with an increased risk of solid malignancies. Here, we show that stomach-specific expression of human IL-1β in transgenic mice leads to spontaneous gastric inflammation and cancer that correlates with early recruitment of myeloid-derived suppressor cells (MDSCs)...

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Detalhes bibliográficos
Main Authors: Tu, Shuiping, Bhagat, Govind, Cui, Guanglin, Takaishi, Shigeo, Kurt-Jones, Evelyn A., Rickman, Barry, Betz, Kelly S., Penz, Melitta, Bjorkdhl, Olle, Fox, James G., Wang, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586894/
https://ncbi.nlm.nih.gov/pubmed/18977329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.10.011
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