Retention of in vitro and in vivo BMP-2 bioactivity in sustained delivery vehicles for bone tissue engineering

In this study, we investigated the in vitro and in vivo biologic activity of bone morphogenetic protein 2 (BMP-2) released from four sustained delivery vehicles for bone regeneration. BMP-2 was incorporated in 1) a gelatin hydrogel, 2) poly(lactic-co-glycolic acid) (PLGA) microspheres embedded in a...

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Main Authors: Kempen, D.H.R., Lu, L., Hefferan, T.E., Creemers, L.B., Maran, A., Classic, K.L., Dhert, W.J.A., Yaszemski, M.J.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577841/
https://ncbi.nlm.nih.gov/pubmed/18472153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2008.04.031
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