Mutational Analysis of the Class IIa Bacteriocin Curvacin A and Its Orientation in Target Cell Membranes

To analyze the orientation in target cell membranes of the pediocin-like bacteriocin (antimicrobial peptide) curvacin A, 55 variants were generated by site-directed mutagenesis and their potencies against four different target cells determined. The result suggest that the somewhat hydrophilic short...

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Bibliographic Details
Main Authors: Haugen, Helén Sophie, Kristiansen, Per Eugen, Fimland, Gunnar, Nissen-Meyer, Jon
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Enzymology and Protein Engineering
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576708/
https://ncbi.nlm.nih.gov/pubmed/18791005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01068-08
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