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Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: Implications for Parkinson’s disease

Degenerating neurons of Parkinson’s disease (PD) patient brains exhibit granules of phosphorylated extracellular signal-regulated protein kinase 1/2 (ERK1/2) that localize to autophagocytosed mito-chondria. Here we show that 6-hydroxydopamine (6-OHDA) elicits activity-related localization of ERK1/2...

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Sonraí Bibleagrafaíochta
Main Authors: Dagda, Ruben K., Zhu, Jianhui, Kulich, Scott M., Chu, Charleen T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574804/
https://ncbi.nlm.nih.gov/pubmed/18594198
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