p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin-induced liver failure

Activation of c-Jun amino-terminal kinase (JNK) facilitates tumour necrosis factor (TNF)-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF stimulation, but it has not been implicated in TNF-induced cell death. Here, we show that hepatocyte-specific ablation of p3...

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Autores principales: Heinrichsdorff, Jan, Luedde, Tom, Perdiguero, Eusebio, Nebreda, Angel R, Pasparakis, Manolis
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2008
Materias:
Scientific Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572111/
https://ncbi.nlm.nih.gov/pubmed/18704119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.149
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