DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage

BACKGROUND: Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers. METHODS: The methylation of 6,502 CpG-rich sequences spanning t...

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Main Authors: Watts, George S, Futscher, Bernard W, Holtan, Nicholas, DeGeest, Koen, Domann, Frederick E, Rose, Stephen L
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566571/
https://ncbi.nlm.nih.gov/pubmed/18826610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-1-47
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