Cancer Genes Hypermethylated in Human Embryonic Stem Cells

Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant...

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Main Authors: Calvanese, Vincenzo, Horrillo, Angelica, Hmadcha, Abdelkrim, Suarez-Álvarez, Beatriz, Fernandez, Agustín F., Lara, Ester, Casado, Sara, Menendez, Pablo, Bueno, Clara, Garcia-Castro, Javier, Rubio, Ruth, Lapunzina, Pablo, Alaminos, Miguel, Borghese, Lodovica, Terstegge, Stefanie, Harrison, Neil J., Moore, Harry D., Brüstle, Oliver, Lopez-Larrea, Carlos, Andrews, Peter W., Soria, Bernat, Esteller, Manel, Fraga, Mario F.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546447/
https://ncbi.nlm.nih.gov/pubmed/18820729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003294
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