Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A

BACKGROUND AND PURPOSE: Screening of 12 000 compounds for binding affinity to the synaptic vesicle protein 2A (SV2A), identified a high-affinity pyrrolidone derivative, brivaracetam (ucb 34714). This study examined its pharmacological profile in various in vitro and in vivo models of seizures and ep...

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Bibliografiske detaljer
Main Authors: Matagne, A, Margineanu, D-G, Kenda, B, Michel, P, Klitgaard, H
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518465/
https://ncbi.nlm.nih.gov/pubmed/18500360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.198
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