Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

The AKT/mammalian target of rapamycin (AKT/mTOR) and ERK MAPK signaling pathways have been shown to cooperate in prostate cancer progression and the transition to androgen-independent disease. We have now tested the effects of combinatorial inhibition of these pathways on prostate tumorigenicity by...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Kinkade, Carolyn Waugh, Castillo-Martin, Mireia, Puzio-Kuter, Anna, Yan, Jun, Foster, Thomas H., Gao, Hui, Sun, Yvonne, Ouyang, Xuesong, Gerald, William L., Cordon-Cardo, Carlos, Abate-Shen, Cory
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2008
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518074/
https://ncbi.nlm.nih.gov/pubmed/18725989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34764
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