Lack of pendrin HCO(3)(-) transport elevates vestibular endolymphatic [Ca(2+)] by inhibition of acid-sensitive TRPV5 and TRPV6 channels

The low Ca(2+) concentration of mammalian endolymph in the inner ear is required for normal hearing and balance. We reported [Yamauchi et al. Biochem Biophys Res Commun, 2005] that the epithelial Ca(2+) channels TRPV5 and TRPV6 are expressed in the vestibular system and that TRPV5 expression is stim...

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Bibliographic Details
Main Authors:	Nakaya, Kazuhiro, Harbidge, Donald G., Wangemann, Philine, Schultz, Bruce D., Green, Eric D., Wall, Susan M., Marcus, Daniel C.
Format:	Artigo
Language:	Inglês
Published:	2007
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2515270/ https://ncbi.nlm.nih.gov/pubmed/17200157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00432.2006
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Lack of pendrin HCO(3)(-) transport elevates vestibular endolymphatic [Ca(2+)] by inhibition of acid-sensitive TRPV5 and TRPV6 channels

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