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Sirolimus blocks the accumulation of hyaluronan (HA) by arterial smooth muscle cells and reduces monocyte adhesion to the ECM

Sirolimus (SRL), an inhibitor of human arterial smooth muscle cell (ASMC) proliferation and migration, prevents in-stent restenosis (ISR). Little is known about the effect of SRL on the extracellular matrix (ECM) component, hyaluronan, a key macromolecule in neointimal hyperplasia and inflammation....

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Sonraí Bibleagrafaíochta
Main Authors: Gouëffic, Yann, Potter-Perigo, Susan, Chan, Christina K., Johnson, Pamela Y., Braun, Kathleen, Evanko, Steven P., Wight, Thomas N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2006
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504412/
https://ncbi.nlm.nih.gov/pubmed/17174314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2006.11.023
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