Sirolimus blocks the accumulation of hyaluronan (HA) by arterial smooth muscle cells and reduces monocyte adhesion to the ECM

Sirolimus (SRL), an inhibitor of human arterial smooth muscle cell (ASMC) proliferation and migration, prevents in-stent restenosis (ISR). Little is known about the effect of SRL on the extracellular matrix (ECM) component, hyaluronan, a key macromolecule in neointimal hyperplasia and inflammation....

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Détails bibliographiques
Auteurs principaux: Gouëffic, Yann, Potter-Perigo, Susan, Chan, Christina K., Johnson, Pamela Y., Braun, Kathleen, Evanko, Steven P., Wight, Thomas N.
Format: Artigo
Langue:Inglês
Publié: 2006
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504412/
https://ncbi.nlm.nih.gov/pubmed/17174314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2006.11.023
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