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Chronic insulin treatment amplifies PDGF-induced motility in differentiated aortic smooth muscle cells by suppressing the expression and function of PTP1B

Hyperinsulinemia plays a major role in the pathogenesis of vascular disease. Restenosis occurs at an accelerated rate in hyperinsulinemia and is dependent on increased vascular smooth muscle cell movement from media to neointima. PDGF plays a critical role in mediating neointima formation in models...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhuang, Daming, Pu, Qinghua, Ceacareanu, Bogdan, Chang, Yingzi, Dixit, Madhulika, Hassid, Aviv
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494764/
https://ncbi.nlm.nih.gov/pubmed/18456732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01105.2007
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