Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes

Toll-like receptor 3 (TLR3) participates in the innate immune response by recognizing viral pathogens. In this study, human brain astrocytes were found to constitutively express TLR3, and this expression was increased by interferon-γ (IFN-γ) or double-stranded RNA (dsRNA). Treatment employing dsRNA...

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Main Authors: Kim, Hyemi, Yang, Eunjung, Lee, Jeonggi, Kim, Se-Hoon, Shin, Jeon-Soo, Park, Joo Young, Choi, Sun Ju, Kim, Se Jong, Choi, In-Hong
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2008
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492940/
https://ncbi.nlm.nih.gov/pubmed/18248388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2007.02799.x
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