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Spontaneous access to DNA target sites in folded chromatin fibers
DNA wrapped in nucleosomes is sterically occluded from many protein complexes that must act on it; how such complexes gain access to nucleosomal DNA is not known. In vitro studies on isolated nucleosomes show that they undergo spontaneous partial unwrapping conformational transitions, which make the...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2481406/ https://ncbi.nlm.nih.gov/pubmed/18485363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.04.025 |
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