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Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 6. Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine
A series of 7,8- and 8,9-fused pyrimidinone, aminopyridine and pyridone derivatives of 8-carboxamidocyclazocine (8-CAC) have been prepared and evaluated in opioid receptor binding assays. Targets were designed to corroborate a pharmacophore hypothesis regarding the bioactive conformation of the carb...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2441872/ https://ncbi.nlm.nih.gov/pubmed/18417347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.03.066 |
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