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Identification of the Major Site of O-Linked β-N-Acetylglucosamine Modification in the C Terminus of Insulin Receptor Substrate-1
Signal transduction from the insulin receptor to downstream effectors is attenuated by phosphorylation at a number of Ser/Thr residues of insulin receptor substrate-1 (IRS-1) resulting in resistance to insulin action, the hallmark of type II diabetes. Ser/Thr residues can also be reversibly glycosyl...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2435407/ https://ncbi.nlm.nih.gov/pubmed/16244361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M500314-MCP200 |
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