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Identification of the Major Site of O-Linked β-N-Acetylglucosamine Modification in the C Terminus of Insulin Receptor Substrate-1

Signal transduction from the insulin receptor to downstream effectors is attenuated by phosphorylation at a number of Ser/Thr residues of insulin receptor substrate-1 (IRS-1) resulting in resistance to insulin action, the hallmark of type II diabetes. Ser/Thr residues can also be reversibly glycosyl...

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Detalhes bibliográficos
Main Authors: Ball, Lauren E., Berkaw, Mary N., Buse, Maria G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435407/
https://ncbi.nlm.nih.gov/pubmed/16244361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M500314-MCP200
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