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Sir2 Silences Gene Transcription by Targeting the Transition between RNA Polymerase II Initiation and Elongation

It is well accepted that for transcriptional silencing in budding yeast, the evolutionarily conserved lysine deacetylase Sir2, in concert with its partner proteins Sir3 and Sir4, establishes a chromatin structure that prevents RNA polymerase II (Pol II) transcription. However, the mechanism of repre...

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Detalhes bibliográficos
Main Authors: Gao, Lu, Gross, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423133/
https://ncbi.nlm.nih.gov/pubmed/18391020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00019-08
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