ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

Mutation in Cu/Zn-superoxide dismutase (SOD1) is a cause of familial amyotrophic lateral sclerosis (ALS). Mutant SOD1 protein (SOD1(mut)) induces motor neuron death, although the molecular mechanism of SOD1(mut)-induced cell death remains controversial. Here we show that SOD1(mut) specifically inter...

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Главные авторы: Nishitoh, Hideki, Kadowaki, Hisae, Nagai, Atsushi, Maruyama, Takeshi, Yokota, Takanori, Fukutomi, Hisashi, Noguchi, Takuya, Matsuzawa, Atsushi, Takeda, Kohsuke, Ichijo, Hidenori
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2008
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2418582/
https://ncbi.nlm.nih.gov/pubmed/18519638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1640108
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