Phase II study of irinotecan with bolus and high dose infusional 5-FU and folinic acid (modified de Gramont) for first or second line treatment of advanced or metastatic colorectal cancer

We investigated the activity of irinotecan given with a more convenient modified bimonthly de Gramont regimen of bolus and infusional 5-fluorouracil [IrMdG] in advanced or metastatic colorectal cancer in the first and second line setting. Irinotecan 180 mg m(−2) was infused over 90 min. L-folinic ac...

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Bibliographic Details
Main Authors: Leonard, P, Seymour, M T, James, R, Hochhauser, D, Ledermann, J A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2002
Subjects:
Clinical
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408897/
https://ncbi.nlm.nih.gov/pubmed/12439708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600641
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