Closing two doors of viral entry: Intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1

We describe a novel strategy in which two inhibitors of HIV viral entry were incorporated into a single molecule. This bifunctional fusion inhibitor consists of an antibody blocking the binding of HIV to its co-receptor CCR5, and a covalently linked peptide which blocks envelope mediated virus-cell...

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Main Authors: Kopetzki, Erhard, Jekle, Andreas, Ji, Changhua, Rao, Eileen, Zhang, Jun, Fischer, Stephan, Cammack, Nick, Sankuratri, Surya, Heilek, Gabrielle
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397382/
https://ncbi.nlm.nih.gov/pubmed/18452606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-5-56
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