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TBL1 and TBLR1 Phosphorylation on Regulated Gene Promoters Overcomes Dual CtBP and NCoR/SMRT Transcriptional Repression Checkpoints

A key strategy to achieve regulated gene expression in higher eukaryotes is to prevent illegitimate signal-independent activation by imposing robust control on the dismissal of corepressors. Here, we report that many signaling pathways, including Notch, NFkB, and nuclear receptor ligands, are subjec...

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Detalhes bibliográficos
Main Authors: Perissi, Valentina, Scafoglio, Claudio, Zhang, Jie, Ohgi, Kenneth A., Rose, David W., Glass, Christopher K., Rosenfeld, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364611/
https://ncbi.nlm.nih.gov/pubmed/18374649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.01.020
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