The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients

The purpose of this study was to investigate the effect of the co-solvents Cremophor EL and polysorbate 80 on the absorption of orally administered paclitaxel. 6 patients received in a randomized setting, one week apart oral paclitaxel 60 mg m(−2) dissolved in polysorbate 80 or Cremophor EL. For 3 p...

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Main Authors: Malingré, M M, Schellens, J H M, Tellingen, O Van, Ouwehand, M, Bardelmeijer, H A, Rosing, H, Koopman, F J, Schot, M E, Huinink, W W Ten Bokkel, Beijnen, J H
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2001
Teme:
Regular Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363961/
https://ncbi.nlm.nih.gov/pubmed/11720431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.2118
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