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Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue

Combretastatin-A4 phosphate (cis -CA-4) is a tubulin-binding agent currently undergoing clinical trials as an anti-tumour drug. We have investigated whether CA-4 functions as a tumour-specific anti-vascular agent using the hyperplastic thyroid as a novel in vivo model of neovascularization. CA-4 eli...

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Bibliografiske detaljer
Main Authors: Griggs, J, Hesketh, R, Smith, G A, Brindle, K M, Metcalfe, J C, Thomas, G A, Williams, E D
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363811/
https://ncbi.nlm.nih.gov/pubmed/11259100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1653
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